High specificity and sensitivity of olfactory bulb synucleinopathy for Lewy body disorders
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چکیده
منابع مشابه
Incidence and Extent of Lewy BodyYRelated >-Synucleinopathy in Aging Human Olfactory Bulb
We investigated the incidence and extent of Lewy body (LB)Y related >-synucleinopathy (LBAS) in the olfactory bulb (OB) in 320 consecutive autopsy patients from a general geriatric hospital (mean age, 81.5 T 8.5 years). Paraffin sections were immunostained with anti-phosphorylated >-synuclein, tyrosine hydroxylase, phosphorylated tau, and amyloid A antibodies. LBAS was found in 102 patients (31...
متن کاملWidespread transneuronal propagation of α-synucleinopathy triggered in olfactory bulb mimics prodromal Parkinson’s disease
Parkinson's disease (PD) is characterized by the progressive appearance of intraneuronal Lewy aggregates, which are primarily composed of misfolded α-synuclein (α-syn). The aggregates are believed to propagate via neural pathways following a stereotypical pattern, starting in the olfactory bulb (OB) and gut. We hypothesized that injection of fibrillar α-syn into the OB of wild-type mice would r...
متن کاملPathology of Neuro-glial Α-synucleinopathy (lewy Body Disease and Multiple System Atrophy)
α-Synucleinopathies comprise a group of neurodegenerative disorders that share α-synuclein (αS) accumulation in selected vulnerable neurons and glia, i.e. Parkinson’s disease (PD), dementia with Lewy bodies and multiple system atrophy (MSA). The histological hallmark of PD is neuronal αS aggregates called Lewy bodies (LBs). LB formation has been considered to be a marker for neuronal degenerati...
متن کاملGlucocerebrosidase gene mutations: a risk factor for Lewy body disorders.
BACKGROUND Mutations in the glucocerebrosidase (GBA) gene have been reported to modify risk for Parkinson disease (PD) and dementia with Lewy bodies (DLB). However, these findings have not been consistently replicated, and most studies have had substantial methodological shortcomings. OBJECTIVE To better assess the role of GBA variants in altering risk for Lewy body disorders. DESIGN Case-c...
متن کاملCholinesterase Inhibitors for Lewy Body Disorders: A Meta-Analysis
BACKGROUND We performed a meta-analysis of cholinesterase inhibitors for patients with Lewy body disorders, such as Parkinson's disease, Parkinson's disease dementia, and dementia with Lewy bodies. METHODS The meta-analysis included only randomized controlled trials of cholinesterase inhibitors for Lewy body disorders. RESULTS Seventeen studies (n = 1798) were assessed. Cholinesterase inhib...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2008
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.22.1_supplement.58.8